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Timothy W. Mackey, D.O. · FL License OS9185 · NPI 1730235797
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Oral testosterone is a prescription capsule, testosterone undecanoate, taken twice a day with food to treat low testosterone in men. NovaGenix prescribes Kyzatrex, an FDA-approved oral testosterone. Dr. Timothy W. Mackey reviews your symptoms, lab work and blood pressure before deciding whether it is appropriate for you.
Modern oral testosterone uses testosterone undecanoate, which is absorbed through the intestinal lymphatic system. That is different from older oral androgens such as methyltestosterone, which carry recognized liver risks. Like injections and creams, oral testosterone replaces testosterone rather than stimulating your body to make more. If keeping your own production matters to you, ask about enclomiphene or hCG.
NovaGenix prescribes Kyzatrex. Jatenzo and Tlando are other FDA-approved oral options that contain the same active ingredient.
| Compare | Kyzatrex | Jatenzo | Tlando |
|---|---|---|---|
| Active ingredient | Testosterone undecanoate | Testosterone undecanoate | Testosterone undecanoate |
| How it's taken | Twice daily with food | Twice daily with food | Twice daily with food |
| Dose approach | Adjusted based on blood tests | Adjusted based on blood tests | Fixed dose |
| Controlled substance | Schedule III | Schedule III | Schedule III |
These products are not interchangeable milligram for milligram. Kyzatrex is taken with food, usually in the morning and evening, and the dose is adjusted based on your blood tests. Sources: Kyzatrex label, Jatenzo label, Tlando label. For a detailed comparison, read Kyzatrex vs. Jatenzo vs. Tlando.
| Compare | Oral capsules | Injections (cypionate) | Cream or gel |
|---|---|---|---|
| Routine | Twice daily with meals | Weekly or as prescribed | Daily on the skin |
| Needles | None | Yes | None |
| Skin-transfer precautions | None | None | Yes |
| Cost at NovaGenix | $349/month, all-inclusive | From $129/month | From $129/month |
None of these is best for every man. Dr. Mackey considers your routine, blood pressure, lab results and budget. See TRT cost and pricing.
Dr. Mackey may consider oral testosterone for a man with symptoms of low testosterone, low testosterone on laboratory testing, and a preference to avoid injections or creams. Whether oral testosterone is right for you is a clinical decision Dr. Mackey makes case by case, based on your symptoms, lab results, blood pressure and health history. It is generally not recommended with uncontrolled high blood pressure, and it is not a fertility-preserving option.
Kyzatrex is a brand-name oral testosterone. Kyzatrex therapy at NovaGenix is $349 per month, all-inclusive of the medication and your care with Dr. Mackey. Costs are reviewed with you by Dr. Mackey and Andy, our clinic manager, before you begin. The male hormone panel is $125 and is billed separately, or recent labs from your own physician can be used. NovaGenix is a direct self-pay practice and does not bill health insurance. NovaGenix will work with a patient to create a superbill if requested.
Oral testosterone can raise blood pressure, so blood pressure is checked before and during treatment. Testosterone can also raise hematocrit (red blood cell levels), which is monitored with bloodwork. Report chest pain, shortness of breath, leg swelling or pain, yellowing of the skin or eyes, or other new symptoms promptly. Learn more about testosterone and blood pressure.
Care at NovaGenix is directed by Timothy W. Mackey, D.O., Medical Director, Florida osteopathic physician license OS9185, NPI 1730235797. NovaGenix has operated in Jupiter since 2016 and holds a Florida Health Care Clinic Establishment Permit, No. 6018496.
Prescription oral testosterone undecanoate, such as Kyzatrex, can raise testosterone in men with confirmed low testosterone, and it avoids needles. Response varies, and the best form depends on your routine, blood pressure and lab results. Dr. Mackey reviews which option fits you.
Yes, when prescribed. Oral testosterone is taken every day, usually twice a day with meals, as directed by your prescriber.
Kyzatrex therapy at NovaGenix is $349 per month, all-inclusive of the medication and your care with Dr. Mackey. The male hormone panel is $125 and is billed separately, or recent labs from your own physician can be used.
No. Oral testosterone is a prescription medication. Over-the-counter testosterone boosters are supplements and are not testosterone replacement.
It can. Like other forms of testosterone therapy, oral testosterone can suppress sperm production. If fertility matters to you, discuss enclomiphene or hCG with Dr. Mackey.
Possibly. Dr. Mackey plans the switch and the lab timing. Do not convert an injection dose into capsules on your own.
Yes, when Dr. Mackey determines it is clinically appropriate. Bloodwork can be done at Labcorp, and Kyzatrex can be shipped to eligible patients anywhere in the U.S.
Call or text NovaGenix at 561-277-8260, or request a consultation online.
This page is for educational purposes and does not replace individualized medical advice. Submitting a form does not create a physician-patient relationship or guarantee treatment. If you are experiencing a medical emergency, call 911.
Written by the NovaGenix Editorial Team · Medically reviewed by Timothy W. Mackey, D.O., Medical Director · Last medically reviewed: November 5, 2026
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Medical Director · NovaGenix Health & Wellness
Dr. Mackey leads physician-directed hormone care at NovaGenix in Jupiter, Florida. He reviews your symptoms, health history and lab results to help you understand your options and build an individualized care plan.
Get to know Dr. Mackey →Learn what you want to know about hormone therapy by scheduling a free consultation.
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