Enclomiphene Therapy for Men With Low Testosterone

Enclomiphene is a prescription oral medication that can help some men with low testosterone make more of their own. At NovaGenix, Dr. Timothy W. Mackey reviews your symptoms, history and lab work before deciding whether enclomiphene is appropriate. Enclomiphene is not FDA-approved as a standalone drug for treating male hypogonadism in the United States.

How Enclomiphene Works

Enclomiphene is a selective estrogen receptor modulator (SERM) and the trans-isomer of clomiphene citrate. By blocking estrogen feedback at the hypothalamus and pituitary, it can increase LH and FSH, which signal the testes to produce testosterone and support sperm production. Testosterone replacement therapy works differently: it supplies testosterone directly and usually suppresses LH, FSH and sperm production. Compare the two in Enclomiphene vs. TRT.

Who May Be a Candidate

Dr. Mackey may consider enclomiphene when a man has:

• Symptoms consistent with low testosterone
• Low testosterone on laboratory testing
• A pattern that suggests secondary or functional hypogonadism (low or inappropriately normal LH), rather than primary testicular failure

It is often discussed when preserving fertility matters. It is less likely to help when the testes themselves can't respond, and it is not appropriate for everyone. Depending on the patient, Dr. Mackey may prescribe enclomiphene on its own, alongside TRT, or when a man is coming off TRT. Because testosterone therapy suppresses the same signals enclomiphene stimulates, adding enclomiphene to TRT should not be assumed to preserve fertility. Read Enclomiphene for Men on TRT.

How to Get an Enclomiphene Prescription at NovaGenix

1. Contact NovaGenix. Call or text 561-277-8260, or request a consultation online.
2. Complete your bloodwork at any Labcorp. The required panel includes total and free testosterone, sensitive estradiol, hematocrit and PSA. Dr. Mackey adds LH, FSH or other tests when he determines they are needed. Recent labs from your own physician can also be used.
3. Review with Dr. Mackey at the Jupiter office, or by telehealth when he determines it is appropriate.
4. If enclomiphene is prescribed, it is prepared by a licensed U.S. compounding pharmacy and shipped to a Florida address, typically in 3–5 business days.
5. Follow-up labs. Dr. Mackey typically checks bloodwork 8 to 10 weeks after you start, to see how you're responding. After that, labs are typically done every 6 to 12 months, or sooner if he decides they're needed. You can also request labs at any time.

Enclomiphene Cost

Enclomiphene therapy at NovaGenix is $99 per month. Your dose and protocol are set by Dr. Mackey, and costs are reviewed with you by Dr. Mackey and Andy, our clinic manager, before you begin treatment. The male hormone panel is $125 and is billed separately, or recent labs from your own physician can be used. NovaGenix is a direct self-pay practice and does not bill health insurance. NovaGenix will work with a patient to create a superbill if requested.

Enclomiphene and Fertility

In clinical trials of men with secondary hypogonadism, enclomiphene raised testosterone while sperm concentrations were maintained. Testosterone gel, by comparison, reduced them. That does not guarantee fertility. Men actively trying to conceive should be evaluated with semen analysis, reproductive history and hormone testing. See TRT and fertility and hCG therapy.

Possible Side Effects and Monitoring

SERM therapy can cause side effects and is medically monitored. Reported concerns with clomiphene-class medications include headache, mood changes, visual symptoms, gastrointestinal symptoms and changes in estradiol or other lab values. Long-term safety data for enclomiphene are more limited than for established testosterone therapies. Report visual changes, severe headache, chest pain, shortness of breath or significant mood changes promptly. NovaGenix and Dr. Mackey are not mental health providers. If mood symptoms are part of what you're experiencing, Dr. Mackey may work with your primary care physician or mental health provider.

Why a Prescription Matters

Enclomiphene is a prescription drug, not a dietary supplement. Avoid online sellers that don't require a valid prescription or can't be verified as licensed pharmacies. Products from unknown sources may be counterfeit, contaminated or mislabeled. A compounded preparation is not FDA-approved, which is why your prescriber should explain the product, its sourcing and how you'll be monitored.

Your Physician

Care at NovaGenix is directed by Timothy W. Mackey, D.O., Medical Director, Florida osteopathic physician license OS9185, NPI 1730235797. NovaGenix has operated in Jupiter since 2016 and holds a Florida Health Care Clinic Establishment Permit, No. 6018496.

Frequently Asked Questions

Is enclomiphene FDA-approved?

No. Enclomiphene is not FDA-approved as a standalone drug for treating male hypogonadism in the United States. A compounded preparation is not FDA-approved either.

Can I buy enclomiphene without a prescription?

No. Enclomiphene is a prescription drug. At NovaGenix it is prescribed only after Dr. Mackey reviews your history and lab work and decides it is appropriate.

How much does enclomiphene cost at NovaGenix?

Enclomiphene therapy at NovaGenix is $99 per month. Costs are reviewed with you by Dr. Mackey and Andy, our clinic manager, before you begin. The male hormone panel is $125 and is billed separately, or recent labs from your own physician can be used.

Is enclomiphene the same as Clomid?

No. Clomid (clomiphene citrate) contains two isomers, enclomiphene and zuclomiphene. Enclomiphene is the trans-isomer on its own. Read Enclomiphene vs. Clomid.

Can enclomiphene be taken with TRT?

In some cases. Depending on the patient, Dr. Mackey may prescribe enclomiphene alongside TRT or when a man is coming off TRT. Because testosterone therapy suppresses the signals enclomiphene stimulates, the combination should not be assumed to preserve fertility.

Does NovaGenix offer enclomiphene by telehealth?

Yes, when Dr. Mackey determines it is clinically appropriate. Bloodwork can be done at Labcorp, and enclomiphene ships to a Florida address, typically in 3–5 business days.

Request a Consultation

Call or text NovaGenix at 561-277-8260, or request a consultation online.

This page is for educational purposes and does not replace individualized medical advice. Submitting a form does not create a physician-patient relationship or guarantee treatment. If you are experiencing a medical emergency, call 911.

Written by the NovaGenix Editorial Team · Medically reviewed by Timothy W. Mackey, D.O., Medical Director · Last medically reviewed: November 4, 2026