HcG Therapy for Patients on TRT

October 7, 2020


The Benefits of Using HCG for Patients on Testosterone Replacement Therapy.

HCG should be part of any Testosterone Replacement Therapy (TRT) protocol for many reasons, however a consultation with a physician is needed prior to starting. One large benefit is that it can help to maintain fertility for men on testosterone and can help increase Spermatogenesis (the production of sperm in the haploid cells in the testes) It will also help to maintain testicular and penis size, assist in cognitive functioning, and increase/improve libido for patients that are on testosterone therapy. There are many clinical trials and peer reviewed studies showing the many benefits and relatively few side effects of this medication making it a safe, effective and sensible part of any hormone replacement protocol for men.What IS HCG and what does it do?HCG is short for Human Chorionic Gonadotropin, which is most famously known as the female pregnancy hormone.  In a male patient on TRT, taking HCG helps because it mimics LH, (Luteinizing Hormone).  When a male's testosterone levels drop below their normal threshold levels, the hypothalamus detects the need for increased hormone production and releases something called Gonadotropin Releasing Hormone (GnRH) which then stimulates the pituitary gland to release LH which then signals the Leydig cells within the testes to produce more testosterone. LH is the main hormone that stimulates Leydig cells in the testes to produce testosterone, so when this is suppressed, men will experience significant changes. For patients who take testosterone injections, the hypothalamus will detect an increase in the overall Serum testosterone levels and stop releasing GnRH which leads to a decrease in LH and FSH being released which will slow down natural testicular functioning and decrease both sperm and testosterone production. Ultimately the testes will begin to atrophy and shrink. For men who are trying to optimize testosterone production and fertility, this is a very unwanted side effect. So for men on TRT using HCG helps in preserving some testicular function and the production of intra-testicular testosterone making it the best option for patients to maintain testicular function, instead of relying solely on exogenous testosterone injections or creams to balance one's hormones. The good news is that hcg can not only prevent this from happening but also will provide additional benefits for men, making it an important part of therapy for men who suffer from Low-T.HCG shares similarities with the LH on a molecular level, but its structure is not chemically identical, which is a good thing for patients on HRT.  Because the half-life of LH is just a few minutes, it makes for a poor medication due to the frequency it would need to taken. LH is released in response to stimulation from GnRH which is secreted by the hypothalamus in pulsations, which means not in a steady stream but in short bursts, this makes taking LH directly problematic. If you wanted to replicate the body's natural release of LH, you'd need to use an LH-analogue that would need to be injected multiple times per daily just to mimic the body's physiological release of LH from the hypothalamus. This is the problem with Gonadorelin, a medication that's being used by some clinics and physicians to replace hCG. Case studies showing the effectiveness of Gonadorelin to replace hCG were done where patients were fitted with pulsatile infusion pumps which would administer a dose every 90 minutes. The alternative is to self inject every hour and a half with an insulin needle but nobody wants to inject themselves several times a day, which makes HCG is a fantastic alternative.  HCG's half-life is approximately 36 hours, allowing patients the option to effectively reach stable blood levels with bi-weekly injections.Some misconceptions that we hear is that HCG is just for fertility and that its only used to "kick start" the natural production of testosterone after taking steroid cycles. This is simply not true and there are plenty of resources which prove otherwise. Unfortunately the majority of physicians who are not experienced in TRT will have little knowledge of this medication and may not prescribe it to their patients which is detrimental to the patient. Another problem that many patients have is that FINDING reasonably priced HCG is extremely difficult now due to recent changes in FDA regulations on who can manufacture hcg. Most compounding pharmacies are no longer able to distribute hcg to their patients and clinics and the fact is that no alternative exists that works as well as hcg, which is why it was an important part of every experienced physician practicing testosterone replacement therapy.NOVAGENIX offers all inclusive TRT programs which includes all physician consultations, lab reviews, follow ups, monitoring medications (including testosterone, anastrozole, hcg), supplies such as syringes, needles, bacteriostatic water, insulin needles and shipping direct to your door.

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  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5666719/
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087849/
  3. https://academic.oup.com/jcem/article/90/5/2595/2836735
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3214853/

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HcG Online available at NovaGenix for patients on TRT

HcG is an important medication used by patients on testosterone therapy. NovaGenix can help offer patients HcG for TRT.[/caption]


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Blood Work Request Form

This subsequent lab panel is necessary for males undergoing Testosterone Replacement Therapy (TRT) through NovaGenix Health and Wellness. It allows physicians to assess the patient's response to prescribed medications, covering sex hormone levels, thyroid function, adrenal health, hematocrit, and liver and kidney function. The panel includes tests such as:

  • Complete Blood Count
  • Comprehensive Metabolic Panel
  • Testosterone (Free and Total)
  • Estradiol Sensitive
  • Thyroid Stimulating Hormone
  • Prostate Specific Antigen

Each test serves a specific purpose in monitoring overall health and treatment effectiveness. When required, Dr Mackey may require LH and FSH (Luteinizing hormone, follicle stimulating hormone) SHBG (Sex hormone binding globulin) or any other tests which may be important for your health and optimizing your hormones.

The Comprehensive Hormone and Wellness Panel for Women offers a foundational assessment of sex hormones, thyroid function, adrenal health, metabolic activity, and overall well-being. This panel serves as a diagnostic tool for identifying testosterone and estrogen deficiencies, assessing health risks, and detecting potential thyroid issues before considering hormone replacement therapy. Additionally, it includes insights into hematocrit (red blood cell volume), as well as liver and kidney function. The panel encompasses various tests such as:

  • Complete Blood Count (CBC)
  • Complete Metabolic Panel
  • Testosterone (free and total)
  • Estradiol
  • Thyroid Stimulating Hormone (TSH)
  • Progesterone

When indicated, Dr. Mackey may require additional tests such as Follicle Stimulating Hormone (FSH), and IGF-1 and Cortisol.

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