Frequently Asked Questions About Testosterone Replacement Therapy

July 14, 2025

Unlocking Vitality: Your FAQs on Testosterone Therapy at NovaGenix

Feeling a persistent dip in energy, a lowering of your libido, or just noticing changes in your overall body composition that just won't budge? You're not alone. Many men start to experience symptoms associated with low testosterone in their 30's and 40's. It's a condition that can significantly impact quality of life, yet fortunately treatable.

At NovaGenix Health and Wellness, we understand these concerns and are committed to helping you navigate the complexities of hormonal health. This FAQ entry we put together will help shed some light on Testosterone Replacement Therapy (TRT), hopefully answering some of the most pressing questions about this type of medical treatment and how it might, how to get started and how we can help you reclaim your vitality and improve your overall health and quality of life.

  • What is Testosterone Replacement Therapy (TRT)? TRT is a medical treatment that involves administering external testosterone to men with abnormally low testosterone levels (hypogonadism) and associated symptoms. At NovaGenix, our goal is to restore hormone balance and fight the symptoms of Low, like low libido, fatigue, and muscle loss with prescription medication, typically testosterone, hCG or enclomiphene. Learn more about TRT here.
  • Who is a candidate for TRT? Men who are experiencing the signs and symptoms of low testosterone, confirmed by blood tests showing consistently low levels of free and/or total testosterone (typically below 300 ng/dL), may be potential candidates for TRT. A comprehensive evaluation by our physician, Dr. Timothy Mackey is needed to determine suitability, eliminate any contraindications as well as rule out other causes for symptoms.
  • What are some of the common symptoms of low testosterone (Low T)?  Everyone is different so symptoms of Low T can include decreased sex drive (libido), erectile dysfunction, persistent fatigue, reduced muscle mass and strength, increased body fat (especially around the midsection), mood changes (like irritability or depression), brain fog, and decreased bone density to name a few of the more common ones.
  • How is TRT administered? TRT can be administered to patients in many different ways. Injections (intramuscular or subcutaneous) are the most popular but for those who don’t wish to use needles, topical gels or creams applied to the skin, patches, and subcutaneous pellets inserted under the skin also work well. The best method for TRT depends on individual preference, lifestyle, and medical needs which can be determined via a consultation with an experienced physician who understands the nuances of hormone therapy for men.
  • What’s the potential benefits of TRT? If you have been tested and have clinically low testosterone, Testosterone treatments can help lead to increased energy, improved sexual functioning (both improved libido and erections), as well as enhanced muscle mass and strength. TRT can also help to reduce body fat, leading to a better, more toned physique, improve confidence and self-esteem, improved mood, cognitive functioning, and increased bone density to name a few.
  • Are there risks or side effects associated with TRT? Yes, like any medical treatment, TRT has potential benefits, risks and side effects. Some of the more common ones include acne or oily skin, fluid retention. More serious, though less common, risks can include an increased red blood cell count, worsening of sleep apnea, and breast enlargement.  However, an experienced provider like Dr. Mackey can help mitigate these risks by adjusting a patient’s protocol, so having a doctor with knowledge of HRT is vital.  It's crucial to discuss all benefits as well as risks with your doctor.
  • How long does it take to see results from TRT?  As all people are unique, the timeline for seeing results varies for individuals. Some men might notice improvements in energy and mood within a few weeks, while more significant physical changes such as increased muscle mass or reduced body fat could take several months (3-6 months or longer). There's many factors which will determine what type of results one may expect to see and how long it takes for them to manifest themselves in the patient. Things like age, lifestyle choices, diet and exercise routines, genetics, medication dose and protocol to name a few when see the onset of TRT benefits.
  • How will my progress be monitored on TRT? For any patient on TRT regular monitoring is essential. Dr. Mackey will typically conduct initial TRT blood tests (including testosterone levels, PSA, and Hematocrit (red blood cell count) before starting therapy. After starting TRT he will request follow-up blood tests at regular intervals (usually 2, 6, and 12 months, to potentially adjust dosage and monitor for side effects.
  • Can TRT affect fertility? Yes, TRT can suppress the body's natural production of testosterone and sperm, potentially leading to reduced fertility or even infertility. Taking testosterone will potentially lower the LH and FSH production which can lower sperm count so If you plan to have biological children, this is a critical consideration to discuss with your doctor before starting TRT. Fortunately, medication like hCG and enclomiphene can reverse this and help maintain natural production of both sperm and testosterone as well as fight testicular atrophy in men on TRT. At NovaGenix we have helped many patients on TRT conceive while on testosterone treatment.
  • Is TRT safe long-term? When administered and monitored by an experienced and qualified healthcare provider like Dr. Mackey at NovaGenix, TRT can be safe for long-term use in appropriate candidates. However, ongoing monitoring is needed to manage potential side effects and assess overall health. TRT is not recommended for men with certain pre-existing conditions like prostate or breast cancer so having an open and honest initial consultation is an important part of this journey.
  • Do You Offer Telemedicine Visits?  Yes, depending on the state you live in and current telemedicine laws, we may be able to provide you with a remote telemedicine appointment. Our partner US based pharmacies will then dispense and deliver medicine to those patients who qualify for treatment, straight to your door!  At NovaGenix we will be there to help with administration and answer any questions that you may have regarding your prescription or protocol any time you need. Just click the following link here and fill out our new patient intake form. Once received, we will reach out and schedule your initial consultation with the doctor.
  • Is treatment covered through my insurance? If you’re looking to get TRT treatment that is covered by your insurance, your best bet is to reach out to your insurance provider to see what their requirements for reimbursement are. Often it involves multiple blood test results showing testosterone levels below a predetermined lab threshold and you may be required to see an in-network provider. Also, the provider may be required to treat you via a protocol determined by the insurance company in order for the provider or clinic to be paid, so you will receive a “cookie cutter approach” to TRT that may not benefit your individual needs as a patient.


Dr. Timothy Wray Mackey, a distinguished physician at NovaGenix, brings extensive expertise in internal medicine and a specialized focus on hormone replacement therapy. A licensed DO with years of experience in both men and women's hormone replacement therapy and weight loss treatments, including a background in the U.S. Army, Dr. Mackey provides personalized care to patients seeking solutions for low testosterone, bioidentical hormone replacement, and various wellness needs. He is certified in anti-aging medicine and bio-identical hormone replacement therapy, ensuring a comprehensive and evidence-based approach to optimizing patient health and well-being.

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Blood Work Request Form

This subsequent lab panel is necessary for males undergoing Testosterone Replacement Therapy (TRT) through NovaGenix Health and Wellness. It allows physicians to assess the patient's response to prescribed medications, covering sex hormone levels, thyroid function, adrenal health, hematocrit, and liver and kidney function. The panel includes tests such as:

  • Complete Blood Count
  • Comprehensive Metabolic Panel
  • Testosterone (Free and Total)
  • Estradiol Sensitive
  • Thyroid Stimulating Hormone
  • Prostate Specific Antigen

Each test serves a specific purpose in monitoring overall health and treatment effectiveness. When required, Dr Mackey may require LH and FSH (Luteinizing hormone, follicle stimulating hormone) SHBG (Sex hormone binding globulin) or any other tests which may be important for your health and optimizing your hormones.

The Comprehensive Hormone and Wellness Panel for Women offers a foundational assessment of sex hormones, thyroid function, adrenal health, metabolic activity, and overall well-being. This panel serves as a diagnostic tool for identifying testosterone and estrogen deficiencies, assessing health risks, and detecting potential thyroid issues before considering hormone replacement therapy. Additionally, it includes insights into hematocrit (red blood cell volume), as well as liver and kidney function. The panel encompasses various tests such as:

  • Complete Blood Count (CBC)
  • Complete Metabolic Panel
  • Testosterone (free and total)
  • Estradiol
  • Thyroid Stimulating Hormone (TSH)
  • Progesterone

When indicated, Dr. Mackey may require additional tests such as Follicle Stimulating Hormone (FSH), and IGF-1 and Cortisol.

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609 N Hepburn avenue suite 106. Jupiter, Florida 33458

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609 N Hepburn avenue suite 106. Jupiter, Florida 33458